2026-05-05T20:47:31Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/748532026-02-06T21:00:59Zcom_10324_1159com_10324_931com_10324_894col_10324_1310
UVaDOC author Novo Díez, Andrea author Horstmann, Jens author Fernández Martínez, Itziar author Calonge, Margarita author González García, María Jesús author Steven, Philipp 2025-02-06T10:32:31Z 2025-02-06T10:32:31Z 2025 The Ocular Surface, enero 2025, vol. 36, p. 173-180 1542-0124 https://uvadoc.uva.es/handle/10324/74853 10.1016/j.jtos.2025.01.014 173 180 The Ocular Surface 36 Purpose: To assess morphological changes in the meibomian glands (MGs) pre- and post-hematopoietic stem cell transplantation (HSCT). Methods: Participants yet to undergo HSCT were included in a pre-HSCT group. Meibography images of both lids were graded using Pult’s meiboscale and analyzed using a semi-automatic software program. Meibography variables in the pre-HSCT group were compared with those in a control group of healthy participants. The follow-up group, a subset of the pre-HSCT group, comprised participants followed up for at least 6 months post-HSCT. Ocular Surface Disease Index (OSDI), tear break-up time, corneal fluorescein staining, and Schirmer test were performed. The differences in meibography variables and ocular surface tests pre- and post-HSCT were analyzed. Results: Pre-HSCT and control groups comprised 181 and 24 participants, respectively. The pre-HSCT group had a higher meiboscale in the lower lid (2 vs. 1, p = 0.011) than controls. The follow-up group comprised 20 patients followed up for 12.75 months post-HSCT. After HSCT, the meiboscale of the upper lid was higher (2 vs. 1, p = 0.011), the MG area was lower in both lids (upper lid = 16.14% vs. 21.49%, p = 0.001; lower lid = 11.92% vs. 17.59%, p = 0.011), and the OSDI increased (15.2 vs. 26.85, p = 0.018) in the second visit compared to the first visit. Conclusions: Alterations in meibography were observed in patients pre- and post-HSCT. This may be attributed to the effect of treatments administered pre-HSCT, although an additive effect of conditioning regimen in the long-term cannot be discarded. eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional Effect of hematopoietic stem cell transplantation on meibomian gland structure info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/74853/1/Novo-Diez_postprint.pdf File MD5 d0e89437bba0a4a5e1eaa97ea3a359fb 1025132 application/pdf Novo-Diez_postprint.pdf