2026-05-05T19:20:11Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/751972025-03-03T20:01:13Zcom_10324_1181com_10324_931com_10324_894col_10324_1387
2025-03-03T10:09:04Z
urn:hdl:10324/75197
Utility of time in tight range (TITR) in evaluating metabolic control in pediatric and adult patients with type 1 diabetes in treatment with advanced hybrid closed-loop systems
Bahillo Curieses, María del Pilar
Fernández Velasco, Pablo
Pérez López, Paloma
Vidueira Martínez, Ana María
Nieto de la Marca, María de la O
Díaz Soto, Gonzalo
Producción Científica
Purpose To analyze the time in tight range (TITR), and its relationship with other glucometric parameters in patients with
type 1 diabetes (T1D) treated with advanced hybrid closed-loop (AHCL) systems.
Methods A prospective observational study was conducted on pediatric and adult patients with T1D undergoing treatment
with AHCL systems for at least 3 months. Clinical variables and glucometric parameters before and after AHCL initiation
were collected.
Results A total of 117 patients were evaluated. Comparison of metabolic control after AHCL initiation showed significant
improvements in HbA1c (6.9 ± 0.9 vs. 6.6 ± 0.5%, p < 0.001), time in range (TIR) (68.2 ± 11.5 vs. 82.5 ± 6.9%, p < 0.001),
TITR (43.7 ± 10.8 vs. 57.3 ± 9.7%, p < 0.001), glucose management indicator (GMI) (6.9 ± 0.4 vs. 6.6 ± 0.3%, p < 0.001),
time below range (TBR) 70–54 mg/dl (4.3 ± 4.5 vs. 2.0 ± 1.4%, p < 0.001), and time above range (TAR) > 180 mg/dl
(36.0 ± 7.6 vs. 15.1 ± 6.4%, p < 0.001). Coefficient of variation (CV) also improved (36.3 ± 5.7 vs. 30.6 ± 3.7, p < 0.001),
while time between 140–180 mg/dl remained unchanged. In total, 76.3% achieved TITR > 50% (100% pediatric). Corre-
lation analysis between TITR and TIR and GRI showed a strong positive correlation, modified by glycemic variability.
Conclusions AHCL systems achieve significant improvements in metabolic control (TIR > 70% in 93.9% patients). The
increase in TIR was not related to an increase in TIR 140–180 mg/dl. Despite being closely related to TIR, TITR allows for a
more adequate discrimination of the achieved control level, especially in a population with good initial metabolic control.
The correlation between TIR and TITR is directly influenced by the degree of glycemic variability.
2025-03-03T10:09:04Z
2025-03-03T10:09:04Z
2024
info:eu-repo/semantics/article
Endocrine, 2024, vol. 86, n. 2, p. 539-545
https://uvadoc.uva.es/handle/10324/75197
10.1007/s12020-024-03881-6
539
2
545
Endocrine
86
1559-0100
eng
https://link.springer.com/article/10.1007/s12020-024-03881-6
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2024 The Author(s)
Atribución 4.0 Internacional
Springer