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oai:uvadoc.uva.es:10324/756132026-02-19T21:00:55Zcom_10324_40357com_10324_952com_10324_894col_10324_40359

Nieto Miguel, Teresa Galindo de la Rosa, Sara López Paniagua, Marina Pérez Soto, María Inmaculada Herreras Cantalapiedra, José María Calonge, Margarita 2025-04-17T11:40:25Z 2025-04-17T11:40:25Z 2019 Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. (2019). Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. 2019, p. 231-262 . 978-3-030-01304-2 978-3-030-01303-5 https://uvadoc.uva.es/handle/10324/75613 231 262 Corneal Regeneration. Therapy and Surgery. Producción Científica Extraocular mesenchymal stem cells (MSCs) represent an available, non-immunogenic source of stem cells that has proved to possess a potential therapeutic value in corneal epithelium regeneration based on results obtained in both preclinical and clinical studies. All published studies have revealed promising results in animal models and have shown significant corneal regeneration, improved corneal transparency and a rapid healing process associated with the restoration of vision. However, the studies performed to unravel the mechanisms underlying the beneficial effects of MSCs on the damaged ocular surface have shown that multiple mechanisms might contribute simultaneously to their therapeutic action. Although it remains uncertain if MSCs can transdifferentiate into corneal epithelial cells, these cells have shown a capacity of secreting trophic and growth factors capable of stimulating resident stem cells and reducing tissue injury, an ability to exert anti-inflammatory and immunomodulatory effects, and a capability to migrate into injured tissues. This book chapter is specifically focused on the preclinical and clinical advancements on the use of extraocular MSCs for corneal epithelium regeneration. Ministerio de Economía y Competitividad y el Fondo Europeo de Desarrollo Regional, España (subvención SAF2015-63594-R MINECO/FEDER, UE) Instituto Nacional de Salud Carlos III, CIBER-BBN (CB06/01/003 MICINN/FEDER, UE) application/pdf eng Springer Nature info:eu-repo/semantics/openAccess Copyright © 2019, Springer Nature Switzerland AG Cornea Ocular surface Cell therapy Mesenchymal stem cells Regeneration 2410 Biología Humana 2407 Biología Celular 3201.09 Oftalmología Cell therapy using extraocular cells: mesenchymal stem cells info:eu-repo/semantics/bookPart info:eu-repo/semantics/accepttedVersion https://doi.org/10.1007/978-3-030-01304-2_17