2026-05-05T13:06:54Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/759252025-09-09T09:37:48Zcom_10324_35294com_10324_952com_10324_894col_10324_35295

Prospective bioconversion of CO2 and CO into fine chemicals via halophilic purple phototrophic bacteria Stegman, Samuel Melkonian, Chrats Tamarit, Daniel Huang Lin, Elisa Lebrero Fernández, Raquel Cantera Ruiz De Pellon, Sara Producción Científica Microbial conversion of cheap and prob- lematic carbon sources, like CO 2 and CO, into fine chemicals offers a promising green alternative to numerous traditionally fossil fuel-based industries such as steel, cement, and pharmaceuticals produc- tion. Purple phototrophic bacteria (PPB) are emerg- ing as versatile key players in carbon–neutral systems due to their anoxygenic photosynthesis and diverse metabolic capabilities, enabling the transformation of carbon and nutrients into a wide range of valua- ble products. Traditionally positioned to treat organic carbon and produce medium-value products like bio- plastics and biomass, PPB also exhibit autotrophic capabilities, enabling the valorization of waste gases, such as CO2 and CO. A key strength of PPB is their metabolic and ecological diversity, including spe- cies inhabiting saline environments. Halophilic bac- teria are known producers of valuable chemicals for pharmaceutical and medical applications, such as osmolytes (ectoine, hydroxyectoine), pigments, amino acids (proline) and natural coenzymes (ubiqui- none), yet halophilic PPB remain underexplored in green upcycling processes. This study identified halophilic PPB capable of transforming waste gases into health and wellness products. Through a compre- hensive literature review, we compiled a list of halo- philic PPB and mined their genomes for genes linked to CO₂/CO utilization as carbon sources. Further genomic search revealed genes encoding enzymes for ectoine/hydroxyectoine, proline, ubiquinone, and carotenoids (lycopene, β-carotene, spirilloxanthin, and spheroidene). We identified 276 genomes of PPB with the genomic potential to valorise CO₂/CO into health-promoting ingredients, highlighting 22 spe- cies capable of producing three or more chemicals simultaneously. These findings highlight the untapped potential of halophilic PPB as bio-platforms for sus- tainable pharmaceutical production. 2025-06-10T11:53:10Z 2025-06-10T11:53:10Z 2025 info:eu-repo/semantics/article Reviews in Environmental Science and Bio/Technology, 2025, vol. 24, n.1, p. 29-41 1569-1705 https://uvadoc.uva.es/handle/10324/75925 10.1007/s11157-025-09722-w 29 1 41 Reviews in Environmental Science and Bio/Technology 24 1572-9826 eng https://link.springer.com/article/10.1007/s11157-025-09722-w info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2025 The Author(s) Atribución 4.0 Internacional Springer SI