2026-04-28T21:00:21Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/77482024-12-12T12:48:44Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Embryonic Cerebrospinal Fluid Activates Neurogenesis of Neural Precursors within the Subventricular Zone of the Adult Mouse Brain Carnicero Gila, Estela María Alonso Revuelta, María Isabel Carretero Soto, Raquel Lamus Molina, José Francisco Moro Balbás, José Antonio Mano Bonín, Anibal de la Fernández Gómez, José María Fidel Gato Casado, Ángel Luis Neurorregeneración Embriología Producción Científica Introduction: There is a nondeveloped neurogenic potential in the adult mammalian brain, which could be the basis for neuroregenerative strategies. Many research efforts have been made to understand the control mechanisms which regulate the transition from a neural precursor to a neuron in the adult brain. Embryonic cerebrospinal fluid (CSF) is a complex fluid which has been shown to play a key role in neural precursor behavior during development, working as a powerful neurogenic inductor. We tested if the neurogenic properties of embryonic CSF are able to increase the neurogenic activity of neuronal precursors from the subventricular zone (SVZ) in the brains of adult mice. Results: Our results show that mouse embryonic CSF significantly increases the neurogenic activity in precursor cells from adult brain SVZ. This intense neurogenic effect was specific for embryonic CSF and was not induced by adult CSF. Conclusions: Embryonic CSF is a powerful neurogenesis inductor in homologous neuronal precursors in the adult brain. This property of embryonic CSF could be a useful tool in neuroregeneration strategies. 2014-12-18 2014-12-18 2013 info:eu-repo/semantics/article Cell Tissues Organs, 2014, vol. 198, n.5, p. 398-404 1422-6405 http://uvadoc.uva.es/handle/10324/7748 10.1159/000356983 398 198 404 Cells Tissues Organs 5 eng https://karger.com/cto/article-abstract/198/5/398/91563/Embryonic-Cerebrospinal-Fluid-Activates?redirectedFrom=fulltext info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © 2014, Silverchair Publisher Attribution-NonCommercial-NoDerivatives 4.0 International Karger