2026-05-05T21:49:35Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/777952025-09-16T20:00:47Zcom_10324_1134com_10324_931com_10324_894col_10324_1213

SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say Fuente Pérez, Sergio De La Producción Científica In adult cardiomyocytes, T-tubules, junctional sarcoplasmic reticulum (jSR), and mitochondria juxtapose each other and form a unique and highly repetitive functional structure along the cell. The close apposition between jSR and mitochondria creates high Ca2+ microdomains at the contact sites, increasing the efficiency of the excitation-contraction-bioenergetics coupling, where the Ca2+ transfer from SR to mitochondria plays a critical role. The SR-mitochondria contacts are established through protein tethers, with mitofusin 2 the most studied SR-mitochondrial "bridge", albeit controversial. Mitochondrial Ca2+ uptake is further optimized with the mitochondrial Ca2+ uniporter preferentially localized in the jSR-mitochondria contact sites and the mitochondrial Na+/Ca2+ exchanger localized away from these sites. Despite all these unique features facilitating the privileged transport of Ca2+ from SR to mitochondria in adult cardiomyocytes, the question remains whether mitochondrial Ca2+ concentrations oscillate in synchronicity with cytosolic Ca2+ transients during heartbeats. Proper Ca2+ transfer controls not only the process of mitochondrial bioenergetics, but also of mitochondria-mediated cell death, autophagy/mitophagy, mitochondrial fusion/fission dynamics, reactive oxygen species generation, and redox signaling, among others. Our review focuses specifically on Ca2+ signaling between SR and mitochondria in adult cardiomyocytes. We discuss the physiological and pathological implications of this SR-mitochondrial Ca2+ signaling, research gaps, and future trends 2025-09-16T12:23:36Z 2025-09-16T12:23:36Z 2019 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion De la Fuente S, Sheu SS. SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say. Arch Biochem Biophys. 2019 Mar 15;663:259-268. doi: 10.1016/j.abb.2019.01.026. Epub 2019 Jan 24. PMID: 30685253; PMCID: PMC6377816. 0003-9861 https://uvadoc.uva.es/handle/10324/77795 10.1016/j.abb.2019.01.026 259 268 Archives of Biochemistry and Biophysics 663 spa info:eu-repo/semantics/openAccess application/pdf https://uvadoc.uva.es/bitstream/10324/77795/3/SR-mitochondria%20communicationin%20adult%20cardiomyocytes%20A%20close%20relationship%20where%20the%20Ca2%2b%20has%20a%20lot%20to%20say.pdf.jpg Hispana TEXT http://rightsstatements.org/vocab/CNE/1.0/ UVaDOC. Repositorio Documental de la Universidad de Valladolid https://uvadoc.uva.es/handle/10324/77795