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00925njm 22002777a 4500 dc Olea Fraile, Elena author Ribeiro, Maria J. author Gallego-Martin, T. author Yubero, S. author Rigual Bonastre, Ricardo Jaime author Masa, J. F. author Obeso Cáceres, Ana María de la Luz author Conde, Silvia V. author González Martínez, Constancio author 2015 Leptin is a hormone produced mostly in adipose tissue and playing a key role in the control of feeding and energy expenditure aiming to maintain a balance between food intake and metabolic activity. In recent years, it has been described that leptin might also contributes to control ventilation as the administration of the hormone reverses the hypoxia and hypercapnia commonly encountered in ob/ob mice which show absence of the functional hormone. In addition, it has been shown that the carotid body (CB) of the rat expresses leptin as well as the functional leptin-B receptor. Therefore, the possibility exists that the ventilatory effects of leptin are mediated by the CB chemoreceptors. In the experiments described below we confirm the stimulatory effect of leptin on ventilation, finding additionally that the CB does not mediate the instant to instant control of ventilation. Adv Exp Med Biol. 2015, vol. 860, p. 379-85. 0065-2598 https://uvadoc.uva.es/handle/10324/77940 10.1007/978-3-319-18440-1_43 379 385 860 2214-8019 The Carotid Body Does Not Mediate the Acute Ventilatory Effects of Leptin