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2025-12-01T08:17:32Z urn:hdl:10324/80181 Development of a Risk Predictive Model for Erectile Dysfunction at 12 Months after COVID-19 Recovery: A Prospective Observational Study Natal Alvarez, Fernando Conde Redondo, María Consuelo Sierrasesumaga Martin, Nicolás García Viña, Alejandro Marfil Peña, Carmen Bahillo Martínez, Alfonso Jojoa Acosta, Mario Fernando Tamayo Gómez, Eduardo Producción Científica Objectives: To develop a risk prediction model for the identification of features involved in the prediction of erectile dysfunction (ED) at 12 months following COVID-19 recovery. Methods: We performed an observational prospective multicentre study. Participants were classified according to their history of COVID-19: (I) patients with a past history of COVID-19 and (II) patients without a previous microbiological diagnosis of COVID-19. A total of 361 patients (past history of COVID-19, n = 166; no past history of COVID-19, n = 195) were assessed from January 2022 to March 2023. Patients with a past history of COVID-19 were assessed at 12 months following COVID-19 recovery. The primary outcome measure was ED, assessed through the 5-item International Index of Erectile Function (IIEF-5). Data concerning epidemiologic variables, comorbidities and active treatment were also collected. We performed a binary logistic regression to develop a risk predictive model. Among the models developed, we selected the one with the higher Area Under the Curve (AUC). Results: The median age was 55 years in both groups. The ED prevalence was 55.9% in patients with past history of COVID-19 and 44.1% in those with no past history of COVID-19. The best predictive model developed for ED comprised 40 variables and had an AUC of 0.8. Conclusions: We developed a regression model for the prediction of ED 12 months after COVID-19 recovery. The application of our predictive tool in a community setting could eventually prevent the adverse effects of ED on cardiovascular health and the associated unfavourable economic impact. 2025-12-01T08:17:32Z 2025-12-01T08:17:32Z 2024 info:eu-repo/semantics/article Journal of Clinical Medicine, 2024, vol. 13, n. 19. p. 5757 2077-0383 https://uvadoc.uva.es/handle/10324/80181 10.3390/jcm13195757 5757 19 Journal of Clinical Medicine 13 2077-0383 eng https://www.mdpi.com/2077-0383/13/19/5757 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional Multidisciplinary Digital Publishing Institute