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oai:uvadoc.uva.es:10324/801812025-12-01T20:08:51Zcom_10324_1191com_10324_931com_10324_894col_10324_1379

Development of a Risk Predictive Model for Erectile Dysfunction at 12 Months after COVID-19 Recovery: A Prospective Observational Study Natal Alvarez, Fernando Conde Redondo, María Consuelo Sierrasesumaga Martin, Nicolás García Viña, Alejandro Marfil Peña, Carmen Bahillo Martínez, Alfonso Jojoa Acosta, Mario Fernando Tamayo Gómez, Eduardo COVID-19 erectile dysfunction cardiovascular disease post-acute COVID-19 syndrome logistic models Producción Científica Objectives: To develop a risk prediction model for the identification of features involved in the prediction of erectile dysfunction (ED) at 12 months following COVID-19 recovery. Methods: We performed an observational prospective multicentre study. Participants were classified according to their history of COVID-19: (I) patients with a past history of COVID-19 and (II) patients without a previous microbiological diagnosis of COVID-19. A total of 361 patients (past history of COVID-19, n = 166; no past history of COVID-19, n = 195) were assessed from January 2022 to March 2023. Patients with a past history of COVID-19 were assessed at 12 months following COVID-19 recovery. The primary outcome measure was ED, assessed through the 5-item International Index of Erectile Function (IIEF-5). Data concerning epidemiologic variables, comorbidities and active treatment were also collected. We performed a binary logistic regression to develop a risk predictive model. Among the models developed, we selected the one with the higher Area Under the Curve (AUC). Results: The median age was 55 years in both groups. The ED prevalence was 55.9% in patients with past history of COVID-19 and 44.1% in those with no past history of COVID-19. The best predictive model developed for ED comprised 40 variables and had an AUC of 0.8. Conclusions: We developed a regression model for the prediction of ED 12 months after COVID-19 recovery. The application of our predictive tool in a community setting could eventually prevent the adverse effects of ED on cardiovascular health and the associated unfavourable economic impact. Instituto de Salud Carlos III (proyecto PI21/00917, PI18/01238, CIBERINFEC CB21/13/00051) Junta de Castilla y León (proyecto GRS 2546/A/22, GRS 2425/A/21, GRS 1922/A/19, GRS 2057/A/19) Consejería de Educación de Castilla y León (proyecto VA256P20) Fundación Ramón Areces (proyecto CIVP19A5953) 2025-12-01T08:17:32Z 2025-12-01T08:17:32Z 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Journal of Clinical Medicine, 2024, vol. 13, n. 19. p. 5757 2077-0383 https://uvadoc.uva.es/handle/10324/80181 10.3390/jcm13195757 5757 19 Journal of Clinical Medicine 13 2077-0383 eng https://www.mdpi.com/2077-0383/13/19/5757 Atribución 4.0 Internacional info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute https://uvadoc.uva.es/bitstream/10324/80181/4/Development%20of%20a%20Risk%20Predictive%20Model%20for%20Erectile%20Dysfunction%20at%2012%20Months%20after%20COVID-19%20Recovery%20A%20Prospective%20Observational%20Study.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by/4.0/ UVaDOC. Repositorio Documental de la Universidad de Valladolid https://uvadoc.uva.es/handle/10324/80181