2026-05-05T19:45:54Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/801812025-12-01T20:08:51Zcom_10324_1191com_10324_931com_10324_894col_10324_1379

Development of a Risk Predictive Model for Erectile Dysfunction at 12 Months after COVID-19 Recovery: A Prospective Observational Study Natal Alvarez, Fernando Conde Redondo, María Consuelo Sierrasesumaga Martin, Nicolás García Viña, Alejandro Marfil Peña, Carmen Bahillo Martínez, Alfonso Jojoa Acosta, Mario Fernando Tamayo Gómez, Eduardo Objectives: To develop a risk prediction model for the identification of features involved in the prediction of erectile dysfunction (ED) at 12 months following COVID-19 recovery. Methods: We performed an observational prospective multicentre study. Participants were classified according to their history of COVID-19: (I) patients with a past history of COVID-19 and (II) patients without a previous microbiological diagnosis of COVID-19. A total of 361 patients (past history of COVID-19, n = 166; no past history of COVID-19, n = 195) were assessed from January 2022 to March 2023. Patients with a past history of COVID-19 were assessed at 12 months following COVID-19 recovery. The primary outcome measure was ED, assessed through the 5-item International Index of Erectile Function (IIEF-5). Data concerning epidemiologic variables, comorbidities and active treatment were also collected. We performed a binary logistic regression to develop a risk predictive model. Among the models developed, we selected the one with the higher Area Under the Curve (AUC). Results: The median age was 55 years in both groups. The ED prevalence was 55.9% in patients with past history of COVID-19 and 44.1% in those with no past history of COVID-19. The best predictive model developed for ED comprised 40 variables and had an AUC of 0.8. Conclusions: We developed a regression model for the prediction of ED 12 months after COVID-19 recovery. The application of our predictive tool in a community setting could eventually prevent the adverse effects of ED on cardiovascular health and the associated unfavourable economic impact. 2025-12-01T08:17:32Z 2025-12-01T08:17:32Z 2025-12-01T08:17:32Z 2024 info:eu-repo/semantics/article Journal of Clinical Medicine, 2024, vol. 13, n. 19. p. 5757 2077-0383 https://uvadoc.uva.es/handle/10324/80181 10.3390/jcm13195757 5757 19 Journal of Clinical Medicine 13 2077-0383 eng https://www.mdpi.com/2077-0383/13/19/5757 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Atribución 4.0 Internacional Multidisciplinary Digital Publishing Institute