2026-04-28T21:15:52Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/805342025-12-12T20:00:37Zcom_10324_1188com_10324_931com_10324_894col_10324_1413

Sánchez-Hernández, Eva Cáceres-González, Claudia García-Valdecasas, José Ignacio Valdez-Ayala, Sintya Martín-Gil, Jesús Martín-Ramos, Pablo 2025-12-12T15:00:50Z 2025-12-12T15:00:50Z 2025 Natural Product Research, 3 July 2025, vol. 39, n.13, p. 3799-3805 1478-6419 https://uvadoc.uva.es/handle/10324/80534 10.1080/14786419.2024.2319658 3799 13 3805 Natural Product Research 39 1478-6427 This study explores the phytochemical composition of leaf extracts from Handroanthus impetiginosus (Mart.) Mattos and Luehea divaricata Mart., used in a contraceptive decoction by Mbya-Guarani women. The phytocompounds were identified by gas chro­matography-mass spectrometry, while Fourier-transform infrared spectroscopy, multi-elemental, and thermal analyses were used to characterise plant biomass. Notably, no phytoconstituent supporting the efficacy of these extracts as female contraceptives was found, except for a small amount (0.3%) of sitosterol. Conversely, L. divaricata leaves contained compounds like 1,3-dihydroxyacetone dimer, N-methyl-N-nitroso-2-propanamine, 2-methoxy-N-(2-methoxyethyl)-N-methyl-ethanamine, and 1,3,5-triazine-2,4,6-triamine, potentially exerting cytotoxic, genotoxic, and toxicogenomic effects. Due to the absence of scientific support for the claimed contraceptive efficacy and the presence of safety concerns, we propose an alternative valorisation pathway centred on the presence of phytochemicals exhibiting antimicrobial activity. This proposition is substantiated by their considerable in vitro efficacy against Botrytis cinerea. spa info:eu-repo/semantics/openAccess Phytochemical study of ‘tajy’ (Handroanthus impetiginosus (Mart.) Mattos) and ‘ka’a ovetĩ’ (Luehea divaricata Mart.) extracts info:eu-repo/semantics/article