2026-04-14T15:59:49Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/809442026-01-08T10:37:45Zcom_10324_1138com_10324_931com_10324_894col_10324_1226
Varga Martínez, Olga de la
Navarro Pérez, R.
López Herrero, Rocío
Montesinos Fadrique, S.
Almoguera Fernández, J.
Alonso Fernández, M.
Artiaga Candia, M.
Becerra Bolaños, A.
Bugueño, N.
Casasempere Sanus, A.
Contreras López, L.
Cuadrillero Sánchez, R.
De la Rosa Estadella, M.
de la Torre Riveiro, I.
del Val Peciña, E.
Delgado Martí, C.
Edo Cebollada, L.
Fernández Fernández, R.
Fernández Rodríguez, J.
Ferrer Gómez, C.
Giné Servén, M.
González Pereira, A.
Guereca Gala, A.
Herrera Soto, A.
Illodo Miramontes, G.
Infantes Morales, M.E.
Marcos Vidal, J.M.
Martínez López, A.
Martínez Ruiz, A.
Martínez Rafael, Beatriz
Matute González, A.
Pariente Juste, L.
Poves Álvarez, Rodrigo
Regueira Fernández, Álvaro
Renedo Fernández, A.
Rodríguez Álvarez, A.A.
Rodríguez Calvo, A.
Rodríguez Conesa, MA
Sánchez González, C.
Tobar Gonzalo, C.
Varela Rodríguez, L.
Veloso de Sousa, R.
Muñoz Moreno, M.F.
Escudero Gómez, G.
Tamayo Gómez, Eduardo
Varela Duran, M.
Badenes Quiles, R.
2025-12-22T10:12:26Z
2025-12-22T10:12:26Z
2025
Journal of Clinical Anesthesia, 2025, vol. 107, p. 112018
0952-8180
https://uvadoc.uva.es/handle/10324/80944
10.1016/j.jclinane.2025.112018
112018
Journal of Clinical Anesthesia
107
Background: Postoperative delirium increases morbidity, mortality, hospital stays, and costs, though 30–40 % of
cases are preventable. This study assessed early delirium incidence in 2442 surgical patients across 43 Spanish
hospitals, analyzing it by surgery type and related factors. Conducted from November 14 and 21, 2023, with
follow-ups on days 2 and 60, it provides insights into factors influencing postoperative delirium and outcomes.
Methods: The study included three phases: (1) recruitment and assessment of surgical patients on November 14
and 21, 2023, across all centers; (2) monitoring for delirium by postoperative day 2; and (3) a follow-up at 60
days. Delirium was diagnosed using the CAM, CAM-ICU, and 4AT scales. The sample size was estimated and
multivariable logistic regression and Cox regression analysis were performed to identify independent risk factors
and assess the impact of delirium on mortality.
Results: A total of 2442 surgical patients were recruited, mainly male (51.9 %), with a mean age of 76 ± 16 years.
The delirium incidence was 3.93 %, with four preoperative independent risk factors identified through multi-
variate analysis.: Patient age (odds ratio (OR) 1.05, 95 % CI 1.04 to 1.08, p > 0.001), cognitive impairment (SBT
> 6 points) (OR 1.12, 95 % CI 1.08 to 1.15, p < 0.001), substance use disorder (SUD) (OR 3.97, 95 % CI 1.05 to
14.93, p = 0.042) and alcoholism (OR 1.92, 95 % CI 1.20 to 3.07, p = 0.006), with a model AUROC of 0.81 (95 %
CI 0.76 to 0.85). Postoperative delirium was associated with longer hospital stays and significantly higher
mortality at 60 days (8.3 % vs 0.6 %).
Conclusion: This Spanish study found that postoperative delirium, linked to longer hospital stays and higher
mortality, requires early detection and prevention to improve outcomes.
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2025 The Author(s)
Atribución 4.0 Internacional
Incidence and risk factors of postoperative delirium after surgery in the spanish population: The DELPO study
info:eu-repo/semantics/article