2026-04-28T01:17:09Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/819542026-04-10T06:19:30Zcom_10324_1132com_10324_931com_10324_894col_10324_1205

Valencia Nieto, Laura García Vázquez, Carmen Fernández Martínez, Itziar Calderón García, Andrés Ángel López De La Rosa, Alberto López Miguel, Alberto Arroyo del Arroyo, Cristina Blanco Vázquez, Marta Novo Díez, Andrea Enriquez De Salamanca Aladro, Amalia González García, María Jesús 2026-01-21T18:03:38Z 2026-01-21T18:03:38Z 2024 Ocular Immunology and Inflammation, 2024, Vol. 32, Nº 10, pp. 2339-2347 0927-3948 https://uvadoc.uva.es/handle/10324/81954 10.1080/09273948.2024.2361114 2339 10 2347 Ocular Immunology and Inflammation 32 1744-5078 Purpose To analyze changes in tear levels of inflammatory mediators in symptomatic contact lens (CL) wearers after refitting with daily disposable CLs and to identify potential biomarkers of success in CL discomfort (CLD) management. Methods Symptomatic CL wearers (CLDEQ-8 ≥ 12) were refitted (V1) with daily disposable CLs (Delefilcon A). After one month (V2), participants were classified into the post-fitting non-symptomatic (CLDEQ <12) and symptomatic (CLDEQ ≥12) groups. At each visit, the participants were clinically evaluated, tears were collected, and 20 inflammatory mediators and substance P (SP) were measured using multiplex immunobead analysis and ELISA, respectively. The detection rates and concentrations were compared between visits and groups, and logistic regression models were performed. Results Forty-three subjects (32 women/11 men; mean age: 23.2 ± 4.9 years) were enrolled. The IL-1β and IL-9 detection rates were higher at V2 (p ≤ 0.044). The detection rates of IL-1β, IL-9, MIP-1α/CCL3, and MMP-9 at V1 (p ≤ 0.045) and IL-17A at V2 (p ≤ 0.014) were higher in the post-fitting symptomatic group. The tear IL-9 concentration was increased at V2 (p = 0.018). The tear concentrations of fractalkine/CX3CL1, IL-2, IL-6, IL-10, MCP-3/CCL7, MIP-1β, NGF, RANTES/CCL5, and TNF-α were higher in the post-fitting symptomatic group (p ≤ 0.044). Additionally, levels of fractalkine/CX3CL1, IL-2, IL-6, IL-10, RANTES/CCL5, and TNF-α at V1 were significantly associated with the post-fitting grouping (p ≤ 0.044). Conclusions Low tear concentrations of specific inflammatory mediators may be used as a predictive biomarker of success for refitting symptomatic CL wearers with daily disposable CLs. However, complementary treatments might be required for symptomatic CL wearers with higher levels of these inflammatory molecules. eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © 2024 The Authors Attribution-NonCommercial-NoDerivatives 4.0 Internacional Lentes de contacto Oftalmología Tear cytokines as predictive biomarkers of success in contact lens discomfort management info:eu-repo/semantics/article