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oai:uvadoc.uva.es:10324/820082026-03-20T11:42:25Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
UVaDOC author Lamo-Espinosa, José María author Prósper, Felipe author Blanco, Juan Francisco author Sánchez Guijo, Fermín author Alberca Zaballos, María Mercedes author García Diaz, Verónica author González-Vallinas Garrachón, Margarita author García-Sancho Martín, Francisco Javier 2026-01-22T11:27:07Z 2026-01-22T11:27:07Z 2021 J Transl Med, Diciembre 2021, vol. 19, n. 1, p. 506. 1479-5876 https://uvadoc.uva.es/handle/10324/82008 10.1186/s12967-021-03160-2 506 1 Journal of Translational Medicine 19 1479-5876 Knee osteoarthritis is the most prevalent joint disease and a frequent cause of pain, functional loss and disability. Conventional treatments have demonstrated only modest clinical benefits whereas cell-based therapies have shown encouraging results, but important details, such as dose needed, long-term evolution or number of applications required are scarcely known. Here we have reanalyzed results from two recent pilot trials with autologous bone marrow-derived mesenchymal stromal cells using the Huskisson plot to enhance quantification of efficacy and comparability. We find that cell doses of 10, 40 and 100 million autologous cells per knee provided quite similar healing results and that much of the effect attained 1 year after cell application remained after 2 and 4 years. These results are encouraging because they indicate that, apart from safety and simplicity: (i) the beneficial effect is both significant and sizeable, (ii) it can be achieved with a single injection of cells, and (iii) the effect is perdurable for years.Trial registration: EudraCT 2009-017405-11; NCT02123368. Registered 25 April 2014-Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02123368?term=02123368&draw=2&rank=1. eng Attribution-NonCommercial-NoDerivatives 4.0 Internacional Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/82008/1/2021%20LAMO-ESPINOSA%20Journal%20of%20Translational%20Medicine.pdf File MD5 d0b898fecb6f4e5b1bd028c2f9665507 792587 application/pdf 2021 LAMO-ESPINOSA Journal of Translational Medicine.pdf