2026-04-27T21:56:39Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/842262026-04-21T19:21:49Zcom_10324_28542com_10324_952com_10324_894col_10324_28543

De La Fuente Ballesteros, Adrián Jano Bascones, Ana Custodio Mendoza, Jorge A. Samanidou, Victoria Mansour, Fotouh R. Ares Sacristán, Ana María Bernal del Nozal, José Producción Científica Cosmetics and personal care products often contain parabens, phthalates, and bisphenols, compounds used as preservatives or plasticizers that may also migrate from packaging materials into the product. Their potential endocrine-disrupting effects have prompted stricter regulations and concentration limits. Given their occurrence and the complexity of cosmetic matrices, several extraction and chromatographic techniques have been developed to ensure reliable quantification. In this review, representative methods published from 2018 to 2025 focused on the determination of these compounds were evaluated using the click analytical chemistry index (CACI), a recently developed color-coded tool that integrates analytical performance, environmental impact, cost, and applicability within a single framework. CACI allows an objective and balanced comparison of analytical methods, emphasizing practicality and real-world feasibility. The obtained CACI scores ranged from 57 to 80, suggesting that the evaluated methodologies can be categorized as acceptable (50-75%) or highly practical (>75%). It is expected that the use of CACI will promote the development of more sustainable, practical, and user-oriented analytical strategies for the evaluation of chromatographic methods, not only for endocrine-disrupting chemicals in cosmetics and personal care products, but also for other substances of interest. 2026-04-21 2026-04-21 2026 info:eu-repo/semantics/article Journal of Chromatography A, 2026, vol. 1778, p. 466990 0021-9673 https://uvadoc.uva.es/handle/10324/84226 10.1016/j.chroma.2026.466990 466990 Journal of Chromatography A 1778 eng https://www.sciencedirect.com/science/article/pii/S0021967326003201 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nd/4.0/ © 2026 The Author(s) Attribution-NoDerivatives 4.0 Internacional Elsevier