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oai:uvadoc.uva.es:10324/842862026-04-24T19:00:35Zcom_10324_1132com_10324_931com_10324_894col_10324_1205

00925njm 22002777a 4500 dc Diez Hermano, Sergio author Sánchez Jiménez, Abel author Aparicio Rodríguez, Gonazalo author Manubens, Paloma author Calvo Tapia, Carlos author Villacorta Atienza, José Antonio author 2026 Statistical inference often relies on p-values to test the absence of effects, but in large datasets, even negligible differences become significant. Evaluating the practical, biological, or clinical magnitude of effects therefore becomes essential. Standardized measures, like Cohen’s d, enable broad comparisons but can obscure practical meaning, like dimensional metrics, such as confidence intervals, which in addition lack standardization. We introduce the similarity structure, a general framework that estimates the probability distribution of sizes of similar subsamples. This method is applicable to any data type, dimensionality or statistical test, and quantifies the effect size as the expected number of observations under similarity, providing a practical interpretation in terms of experimental effort, and extends Cohen’s d effect sizes to parameters beyond the mean. The method also enables the comparison of effect sizes –within the same study or across studies–through direct statistical inference, clarifying the relevance of observed differences. The similarity structure, applied here to real datasets, offers a general, transparent and versatile approach for interpreting and comparing effects in large-sample studies. PNAS Nexus (en revisión, preprint) https://uvadoc.uva.es/handle/10324/84286 Real significance in large datasets: the similarity structure, a general method to assess the effect size beyond p-value