2024-03-29T09:37:12Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/509692022-01-05T21:46:51Zcom_10324_1179com_10324_931com_10324_894col_10324_1306
Oppenheimer Salinas, Federico
Aljama García, Pedro
Asensio Peinado, Concepción
Bustamante Bustamante, Jesús
Crespo Albiach, Jose Francisco
Guirado Perich, Luis
2021-12-17T09:47:08Z
2021-12-17T09:47:08Z
2004
Nephrology Dialysis Transplantation, 2004, vol. 19, supl. 3, p. 11–15
0931-0509
https://uvadoc.uva.es/handle/10324/50969
10.1093/ndt/gfh1008
iii11
suppl_3
iii15
Nephrology Dialysis Transplantation
19
1460-2385
Producción Científica
Background. The use of elderly donors is becoming more frequent. An increase in the donor’s age is
associated with a greater incidence of delayed graft function (DGF), chronic allograft nephropathy (CAN)
and worse graft survival. Poor renal graft function is a risk factor for cardiovascular (CV) complications
and, finally, for mortality of the patients. Methods. A total of 3365 adult patients transplanted in 1990 (n¼824), 1994 (n¼1075) and 1998 (n¼1466) with a functioning graft after the first year were included. The impact of donor age on renal function, DGF, acute rejection and other clinical factors was
evaluated according to two donor and recipient age categories: young (<60 years old) and elderly (>60
years old). Additionally, donor age was categorized by decades for the analysis of patient and graft survival, acute rejection and CV mortality. Results. Donor mean age significantly increased during the three transplantation periods. A total of 478 out of 3365 donors were older than 60 years. Elderly donors showed an increased risk of DGF (38.9 vs 28.8%) and CAN (56.8 vs 46.2%). Mean serum creatinine at 3 and 12 months and proteinuria were significantly higher in the old donor group. Incidence and severity of acute rejection were similar in both groups. Graft and patient survival were significantly lower in the old donor group. Also, risk of mortality due to CV events was also significantly higher. A linear increase in risk of graft loss, patient death or CV mortality was observed when donor age was divided into 10 year increase subsets. Conclusions. Donor age is a strong predictor of CAN and graft loss. Patient survival is also affected by donor age, particularly by a higher risk of CV mortality.
application/pdf
eng
Oxford University Press
European Renal Association
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2004 Oxford University Press
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Riñones - Trasplante
Survival
Supervivencia
Riñones - Enfermedades
Cardiovascular risk
Riesgo cardiovascular
3205.06 Nefrología
3205.01 Cardiología
The impact of donor age on the results of renal transplantation
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
https://academic.oup.com/ndt/article/19/suppl_3/iii11/1826911
SI