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Parada, Carolina Gato Casado, Ángel Luis Bueno i Torrens, David 2014-09-03T08:46:02Z 2014-09-03T08:46:02Z 2008 Developmental Neuroscience, June 2008, vol. 19, n. 9. p. 945-950 0378-5866 http://uvadoc.uva.es/handle/10324/5797 945 9 950 Developmental Neuroscience 19 Producción Científica Embryonic cerebrospinal £uid (E-CSF) is involved in the regulation of survival, proliferation and neurogenesis of neuroectodermal progenitor cells, aswell as in the control ofmesencephalic gene expression in collaboration with the isthmic organizer. Recently, we showed the presence of retinol-binding protein (RBP) within the E-CSF proteome.RBP is an all-trans retinol carrier, amolecule that can be metabolized into retinoic acid, a morphogen involved in central nervous system (CNS) morphogenesis and patterning. Here we demonstrate the presence of all-trans retinol within the E-CSF and analyse the dynamics of RBP and all-trans retinolwithin this £uid, as well as the expression of retinoic acid-synthesizing enzymes during early CNS development. Our results suggest a relationship between the dynamics of these molecules and the early events of CNS patterning. application/pdf eng Lippincott Williams and Wilkins info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Lippincott Williams and Wilkins Attribution-NonCommercial-NoDerivatives 4.0 International Fluidos orgánicos Retinol Embriología humana Cerebro - Desarrollo All-trans retinol and retinol-binding protein from embryonic cerebrospinal £uid exhibit dynamic behaviour during early central nervous system development info:eu-repo/semantics/article SI