2026-07-22T05:14:34Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/590952025-03-07T08:17:10Zcom_10324_1179com_10324_931com_10324_894col_10324_1306

Gorgojo Galindo, Óscar Martín Fernández, Marta Peñarrubia Ponce, María Jesús Álvarez González, Francisco Javier Ortega Loubon, Christian Joseph Gonzalo Benito, Hugo Martínez de Paz, Pedro José Miramontes González, José Pablo Gómez Sánchez, Esther Poves Álvarez, Rodrigo Jorge Monjas, Pablo Tamayo Gómez, Eduardo Heredia Rodríguez, María Tamayo Velasco, Álvaro 2023-04-13T07:44:57Z 2023-04-13T07:44:57Z 2021 Journal of Clinical Medicine, 2021, Vol. 10, Nº. 22, 5431 2077-0383 https://uvadoc.uva.es/handle/10324/59095 10.3390/jcm10225431 5431 22 Journal of Clinical Medicine 10 2077-0383 Producción Científica Pneumonia is the main cause of hospital admission in COVID-19 patients. We aimed to perform an extensive characterization of clinical, laboratory, and cytokine profiles in order to identify poor outcomes in COVID-19 patients. Methods: A prospective and consecutive study involving 108 COVID-19 patients was conducted between March and April 2020 at Hospital Clínico Universitario de Valladolid (Spain). Plasma samples from each patient were collected after emergency room admission. Forty-five serum cytokines were measured in duplicate, and clinical data were analyzed using SPPS version 25.0. Results: A multivariate predictive model showed high hepatocyte growth factor (HGF) plasma levels as the only cytokine related to intubation or death risk at hospital admission (OR = 7.38, 95%CI—(1.28–42.4), p = 0.025). There were no comorbidities included in the model except for the ABO blood group, in which the O blood group was associated with a 14-fold lower risk of a poor outcome. Other clinical variables were also included in the predictive model. The predictive model was internally validated by the receiver operating characteristic (ROC) curve with an area under the curve (AUC) of 0.94, a sensitivity of 91.7% and a specificity of 95%. The use of a bootstrapping method confirmed these results. Conclusions: A simple, robust, and quick predictive model, based on the ABO blood group, four common laboratory values, and one specific cytokine (HGF), could be used in order to predict poor outcomes in COVID-19 patients. Instituto de Salud Carlos III - ( Proyecto COV20/00491) Consejeria de Educación de Castilla y León - (Proyecto VA256P20) Junta de Castilla y León y Fondo Europeo de Desarrollo Regional (FEDER) - (Proyecto EDU/1100/2017) application/pdf eng MDPI info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2021 The authors Atribución 4.0 Internacional COVID-19 COVID-19 (Disease) - Diagnosis Coronaviruses - Diagnosis Cytokines - Therapeutic use Biomarkers 2420 Virología Predictive modeling of poor outcome in severe COVID-19: A single-center observational study based on clinical, cytokine and laboratory profiles info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://www.mdpi.com/2077-0383/10/22/5431 SI