2024-03-28T08:35:10Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/98172021-06-23T09:49:15Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Simarro Grande, María
Giannattasio, Giorgio
Benarafa, Charaf
Subramanian, Kulandayan K.
Ishizawar, Rumey
Balestrieri, Barbara
Andersson, Emma M.
Luo, Hongbo R.
Orduña Domingo, Antonio
Boyce, Joshua
Fuente García, Miguel Ángel de la
2015-03-20T08:26:56Z
2015-03-20T08:26:56Z
2010
J Immunol. 2010; 184(9): 5325–5332.
0022-1767
http://uvadoc.uva.es/handle/10324/9817
10.4049/jimmunol.1000104
5325
9
5332
Journal of Immunology
184
Producción Científica
We generated Fas-activated serine threonine phosphoprotein (FAST)-deficient mice (FAST−/−) to study the in vivo role of FAST in immune system function. In a model of house dust mite-induced allergic pulmonary inflammation, wild type mice develop a mixed cellular infiltrate composed of eosinophils, lymphocytes, and neutrophils. FAST−/− mice develop airway inflammation that is distinguished by the near absence of neutrophils. Similarly, LPS-induced alveolar neutrophil recruitment is markedly reduced in FAST−/− mice compared with wild type controls. This is accompanied by reduced concentrations of cytokines (TNF-α and IL-6 and -23) and chemoattractants (MIP-2 and keratinocyte chemoattractant) in bronchoalveolar lavage fluids. Because FAST−/− neutrophils exhibit normal chemotaxis and survival, impaired neutrophil recruitment is likely to be due to reduced production of chemoattractants within the pulmonary parenchyma. Studies using bone marrow chimeras implicate lung resident hematopoietic cells (e.g., pulmonary dendritic cells and/or alveolar macrophages) in this process. In conclusion, our results introduce FAST as a proinflammatory factor that modulates the function of lung resident hematopoietic cells to promote neutrophil recruitment and pulmonary inflammation.
application/pdf
eng
American Association of Immunologists
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Sistema inmunitario-Enfermedades
Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation
info:eu-repo/semantics/article
SI