2024-03-29T00:27:13Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/68522021-06-23T09:51:11Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
Rocher Martín, María Asunción
Cáceres Pereira, Ana Isabel
Obeso Cáceres, Ana María de la Luz
González, Constancio
2011
Producción Científica
Abstract: Carotid bodies (CBs) are secondary sensory receptors in which the sensing
elements, chemoreceptor cells, are activated by decreases in arterial PO2 (hypoxic
hypoxia). Upon activation, chemoreceptor cells (also known as Type I and glomus cells)
increase their rate of release of neurotransmitters that drive the sensory activity in the
carotid sinus nerve (CSN) which ends in the brain stem where reflex responses are
coordinated. When challenged with hypoxic hypoxia, the physiopathologically most
relevant stimulus to the CBs, they are activated and initiate ventilatory and cardiocirculatory
reflexes. Reflex increase in minute volume ventilation promotes CO2 removal from alveoli
and a decrease in alveolar PCO2 ensues. Reduced alveolar PCO2 makes possible alveolar
and arterial PO2 to increase minimizing the intensity of hypoxia. The ventilatory effect, in
conjunction the cardiocirculatory components of the CB chemoreflex, tend to maintain an
adequate supply of oxygen to the tissues. The CB has been the focus of attention since the
discovery of its nature as a sensory organ by de Castro (1928) and the discovery of its
function as the origin of ventilatory reflexes by Heymans group (1930). A great deal of
effort has been focused on the study of the mechanisms involved in O2 detection. This
review is devoted to this topic, mechanisms of oxygen sensing. Starting from a summary of
the main theories evolving through the years, we will emphasize the nature and significance
of the findings obtained with veratridine and tetrodotoxin (TTX) in the genesis of current
models of O2-sensing.
application/pdf
http://uvadoc.uva.es/handle/10324/6852
eng
Multidisciplinary Digital Publishing Institute
Neurofisiología
Tetrodotoxin as a Tool to Elucidate Sensory Transduction Mechanisms: The Case for the Arterial Chemoreceptors of the Carotid Body
info:eu-repo/semantics/article
TEXT
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