2024-03-29T15:32:38Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/103802021-06-23T09:49:11Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
CD148, a membrane protein tyrosine phosphatase, is able to induce tyrosine phosphorylation on human lymphocytes
Palou, Eduard
Fuente García, Miguel Ángel de la
Nicolás, Josep Maria
Vilardell, Carme
Vives, Jordi
Gayá, Antoni
Células hematopoyéticas
Hematología
Producción Científica
CD148 is a new cluster of differentiation defined in the VI International Workshop on Leucocyte Differentiation Antigens. It has been identified as the hematopoietic form of a formerly described membrane protein tyrosine phosphatase called HPTP eta/ DEP-1. Previous data have demonstrated that this molecule is able to give rise to [Ca2+]i increase. In the present work we show its capability to induce protein tyrosine phosphorylation in human lymphocytes in spite of its intrinsic protein tyrosine phosphatase activity. The induction of kinase activity suggests the involvement of some protein tyrosine kinase based signaling pathway. The activation of this postulated kinase could be carried out through a direct association or via an adapter molecule.
2015-04-10T11:29:46Z
2015-04-10T11:29:46Z
1997
info:eu-repo/semantics/article
Immunology Letters, 1997, 57(1-3):101-103
0165-2478
http://uvadoc.uva.es/handle/10324/10380
10.1016/S0165-2478(97)00069-2
101
1-3
103
Immunology Letter
57
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
application/pdf
Elsevier
https://uvadoc.uva.es/bitstream/10324/10380/6/23.%20M.A.%20de%20la%20Fuente%20PD-234.pdf.jpg
Hispana
TEXT
http://creativecommons.org/licenses/by-nc-nd/4.0/
UVaDOC. Repositorio Documental de la Universidad de Valladolid
http://uvadoc.uva.es/handle/10324/10380