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Enantioselective Synthesis of Seven-Membered Carbo- and Heterocyles by Organocatalyzed Intramolecular Michael Addition Guevara Pulido, James Oswaldo Andrés García, José María Ávila, Deisy P. Pedrosa Sáez, Rafael Química orgánica Producción Científica Unprecedented diastereo- and enantioselective synthesis of seven-membered rings has been achieved by organocatalyzed intramolecular Michael addition of enals bearing β-diketone functionality. The cyclization leads to 2,3-disubstituted cycloheptanone derivatives in high yield and excellent stereoselectivity. The same organocatalyzed cyclization process has been used to prepare six-membered homologs, but with lower stereoselectivity. Ministerio de Economía, Industria y Competitividad (CTQ 2011-28487) Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA064U13) Universidad de Valladolid for a pre-doctoral fellowships 2016-12-05T13:48:27Z 2016-12-05T13:48:27Z 2016 info:eu-repo/semantics/article RSC Advances, 2016, 6, p. 30166-30169 http://uvadoc.uva.es/handle/10324/21452 10.1039/C6RA04198A 30166 6 30169 RSC Advances eng http://pubs.rsc.org/ Attribution-NonCommercial-NoDerivatives 4.0 International info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Royal Society of Chemistry https://uvadoc.uva.es/bitstream/10324/21452/6/RSC-Adv-2016-6.pdf.jpg Hispana TEXT http://creativecommons.org/licenses/by-nc-nd/4.0/ UVaDOC. Repositorio Documental de la Universidad de Valladolid http://uvadoc.uva.es/handle/10324/21452