2024-03-29T09:50:09Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/409922023-03-17T11:32:32Zcom_10324_1181com_10324_931com_10324_894col_10324_1387
Elderberries: A source of ribosome-inactivating proteins with lectin activity
Tejero del Río, Jesús
Jiménez López, María del Pilar
Quinto Fernández, Emiliano José
Córdoba Diaz, Damián
Garrosa García, Manuel
Córdoba Diaz, Manuel
Gayoso Rodríguez, Manuel José
Girbés Juan, Tomás
Dwarf elder
Saúco menor
Black elder
Saúco negro
Ebulin
Ebulina
Immunotoxins
Inmunotoxinas
Producción Científica
Sambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses.
Junta de Castilla y León (Grupo de Excelencia GR106)
Universidad Complutense de Madrid (research group 950247)
2020-06-04T13:01:18Z
2020-06-04T13:01:18Z
2015
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Molecules, 2015, vol. 20, n. 2. p. 2364-2387
1420-3049
http://uvadoc.uva.es/handle/10324/40992
10.3390/molecules20022364
eng
https://www.mdpi.com/1420-3049/20/2/2364
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2015 MDPI
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MDPI
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Hispana
TEXT
http://creativecommons.org/licenses/by-nc-nd/4.0/
UVaDOC. Repositorio Documental de la Universidad de Valladolid
http://uvadoc.uva.es/handle/10324/40992