2024-03-28T09:45:33Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/467462022-07-18T09:33:09Zcom_10324_35294com_10324_952com_10324_894col_10324_35295
Voltammetric study of triazole antifungal agent terconazole on sp3 and sp2 carbon-based electrode materials
Fischer, Jan
González Martín, Javier
Lochyński, Paweł
Dejmková, Hana
Schwarzová Pecková, Karolina
Vega, Marisol
Voltamétrico
Terconazol
23 Química
24 Ciencias de la Vida
Producción Científica
Terconazole belongs to synthetic triazole antifungal agents, inhibiting biosynthesis of ergosterol or other sterols and thus disrupting cell wall synthesis in fungi. In this study, electrochemical behavior of terconazole was studied for the first time using cyclic voltammetry and differential pulse voltammetry on boron doped diamond electrode (BDD) with different surface treatments leading to O-terminated, H-terminated and polished surfaces, as well as on glassy carbon (GCE) and basal-plane pyrolytic graphite electrodes (PGE). Terconazole is not reducible within the potential window on these electrode materials. It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 in two steps due to the presence of piperazine ring in its molecule, possessing two redox centers at the tertiary nitrogen atoms, by an ECE mechanism. Optimal conditions were found for determination of terconazole in 0.1 mol L−1 phosphate buffer pH 7.2. Using differential pulse voltammetry, the lowest detection limit of 0.40 μmol L−1 and excellent repeatability (RSD 1.1%) were achieved on O-terminated BDD when in-situ anodic activation was used prior to each scan. This is beneficial in comparison with GCE and PGE; their necessity of ex-situ polishing worsens the signal repeatability (RSD ~ 4%) and detection limits reaching 0.50 μmol L−1 and 1.23 μmol L−1, respectively.
Czech Science Foundation (project 18-01710S) and carried out within the framework of Specific University Research (SVV 260440)
Junta de Castilla y León y EU-FEDER (CLU 2017-09)
2021-06-04T10:12:37Z
2021-06-04T10:12:37Z
2020
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
Journal of Electroanalytical Chemistry, 2020, vol. 863, p. 114054
1572-6657
https://uvadoc.uva.es/handle/10324/46746
10.1016/j.jelechem.2020.114054
114054
Journal of Electroanalytical Chemistry
863
eng
https://www.sciencedirect.com/science/article/abs/pii/S157266572030237X
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2020 Elsevier
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Elsevier
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Hispana
TEXT
http://creativecommons.org/licenses/by-nc-nd/4.0/
UVaDOC. Repositorio Documental de la Universidad de Valladolid
https://uvadoc.uva.es/handle/10324/46746