2024-03-29T11:02:01Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/513832022-09-30T10:51:03Zcom_10324_1185com_10324_931com_10324_894col_10324_1346
Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
Escobedo Monge, Marlene Fabiola
Torres Hinojal, María Carmen
Barrado Esteban, Enrique
Escobedo Monge, María Antonieta
Marugán de Miguelsanz, José Manuel
Parodi Román, Joaquín
Hypocupremia
Hipocupremia
Hypercupremia
Hipercupremia
Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropomet-ric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaning-fully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.
2022-01-14T10:43:29Z
2022-01-14T10:43:29Z
2021
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Nutrients, 2021, vol. 13, 3578
2072-6643
https://uvadoc.uva.es/handle/10324/51383
10.3390/nu13103578
3578
NUTRIENTS
13
eng
https://www.mdpi.com/2072-6643/13/10/3578
info:eu-repo/semantics/openAccess
© 2021 The Authors
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MDPI
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https://uvadoc.uva.es/handle/10324/51383