2024-03-28T09:32:33Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/98282021-06-23T09:49:23Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
3BP2 Deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation
Fuente García, Miguel Ángel de la
Kumar, Lalit
Lu, Bao
Geha, Raif S.
Biología celular
Producción Científica
The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-γ (PLC-γ); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell development, proliferation, cytokine secretion, and signaling in response to T-cell receptor (TCR) ligation were all normal in 3BP2−/− mice. 3BP2−/− mice had increased accumulation of pre-B cells in the bone marrow and a block in the progression of transitional B cells in the spleen from the T1 to the T2 stage, but normal numbers of mature B cells. B-cell proliferation, cell cycle progression, PLC-γ2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to B-cell receptor (BCR) ligation were all impaired. These results suggest that 3BP2 is important for BCR, but not for TCR signaling.
2015-03-24T10:24:59Z
2015-03-24T10:24:59Z
2006
info:eu-repo/semantics/article
Molecular and Cellular Biology, 2006, vol. 26, n. 14. p. 5214–5225
0270-7306
http://uvadoc.uva.es/handle/10324/9828
10.1128/MCB.00087-06
10.1128/MCB.00087-06
5214
14
5225
Molecular and Cellular Biology
26
eng
https://mcb.asm.org/content/26/14/5214.long
Attribution-NonCommercial-NoDerivatives 3.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
application/pdf
American Society for Microbiology
https://uvadoc.uva.es/bitstream/10324/9828/6/9.%20M.A.%20de%20la%20Fuente%20PD-222.pdf.jpg
Hispana
TEXT
http://creativecommons.org/licenses/by-nc-nd/4.0/
UVaDOC. Repositorio Documental de la Universidad de Valladolid
http://uvadoc.uva.es/handle/10324/9828