2026-03-08T20:44:33Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/214522021-06-24T07:42:20Zcom_10324_1187com_10324_931com_10324_894com_10324_28542com_10324_952col_10324_1408col_10324_28543
Enantioselective Synthesis of Seven-Membered Carbo- and Heterocyles by Organocatalyzed Intramolecular Michael Addition
Guevara Pulido, James Oswaldo
Andrés García, José María
Ávila, Deisy P.
Pedrosa Sáez, Rafael
Química orgánica
Producción Científica
Unprecedented diastereo- and enantioselective synthesis of seven-membered rings has been achieved by organocatalyzed intramolecular Michael addition of enals bearing β-diketone functionality. The cyclization leads to 2,3-disubstituted cycloheptanone derivatives in high yield and excellent stereoselectivity. The same organocatalyzed cyclization process has been used to prepare six-membered homologs, but with lower stereoselectivity.
2016-12-05
2016-12-05
2016
info:eu-repo/semantics/article
RSC Advances, 2016, 6, p. 30166-30169
http://uvadoc.uva.es/handle/10324/21452
10.1039/C6RA04198A
30166
6
30169
RSC Advances
eng
http://pubs.rsc.org/
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 International
Royal Society of Chemistry