2024-03-29T04:56:23Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/41812021-09-14T08:45:02Zcom_10324_1181com_10324_931com_10324_894col_10324_1387
Citokine, chemokine and immune activation pathway profiles in celiac disease : an immune system activity screening by expression macroarrays.
Garrote Adrados, José Antonio
Gómez, Emma
León, Alberto José
Bernardo Ordiz, David
Calvo Romero, María del Carmen
Fernández Salazar, Luis Ignacio
Blanco Quirós, Alfredo
Arranz Sanz, Eduardo
Enfermedad celíaca
Producción Científica
The aims of the study were to assess the usefulness of expression macroarrays to determine the pattern of expression
of cytokines, chemokines and molecules related to immune system activation pathways, in non-stimulated intact intestinal
tissue specimens from patients with active CD (aCD) and on a gluten-free diet (GFD), to compare it with two groups of
controls with either normal or altered mucosal architecture, and to establish putative targets for diagnostic markers or
therapeutic intervention. We have experienced the lack of sensitivity to detect signal of genes with low level of expression.
In spite of that, active CD seems to show a Th1 cytokine pattern, but with signs of Th2 activity. Cytokines such as IL-9,
IL-11, IL-21 or MIF might be involved in mucosal infl ammation in CD. In GFD, some memory cells and DC’s activity
remains, and factors that maintain this remnant activation might be responsible of the fast mucosal response on gluten challenge.
STAT3 and STAT5 pathways, and their regulatory molecules SOCS’s may result keys for understanding mucosal
infl ammation in gut and putative targets for further research.
2014-01-16
2014-01-16
2008
info:eu-repo/semantics/article
Drug Target Insights, 3. p. 1-11
1177-3928
http://uvadoc.uva.es/handle/10324/4181
1
3
11
Drug target insights
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Libertas Academica
Attribution-NonCommercial-NoDerivatives 4.0 International
Instituto de Biología y Genética Molecular (IBGM)