2024-03-29T08:27:12Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/457602021-06-23T09:56:45Zcom_10324_1138com_10324_931com_10324_894col_10324_1226
Cholesterol-lowering treatment in chronic kidney disease: multistage pairwise and network meta-analyses
Herrera Gómez, Francisco Magno
Chimeno Viñas, María Montserrat
Martín García, Débora
Lizaraso Soto, Frank
Maurtua Briseño Meiggs, Álvaro
Grande Villoria, Jesús
Bustamante Munguira, Juan
Alamartine, Eric
Vilardell, Miquel
Ochoa Sangrador, Carlos
Álvarez González, Francisco Javier
Producción Científica
Pairwise and network meta-analyses on the relationship between the efficacy of the use of statins with or without ezetimibe and reductions in low-density lipoprotein cholesterol (LDLc) and C-reactive protein (CRP) in patients with chronic kidney disease (CKD) are presented. In the pairwise meta-analysis, statins with or without ezetimibe were shown to be efficacious in reducing major adverse cardiovascular events (MACE) in patients with CKD and an estimated glomerular filtration rate (eGFR) of less than 60 ml/min/1.73 m2, in the context of both primary prevention [odds ratio (OR)/95% confidence interval (95% CI)/I2/number of studies (n): 0.50/0.40–0.64/0%/6] and primary/secondary prevention (0.66/0.57–0.76/57%/18). However, in the Bayesian network meta-analysis, compared to the placebo, only atorvastatin 80 mg daily and atorvastatin and rosuvastatin at doses equivalent to simvastatin 20 mg daily reduced the odds of MACEs in this patient population. The network meta-analysis for LDLc and CRP treatment objectives also showed that, regardless of eGFR and excluding dialysis patients, the number of MACEs decreased in patients with CKD, with reductions in both LDLc and CRP of less than 50% (surface under the cumulative ranking (SUCRA)/heterogeneity (vague)/n: 0.77/0.14/3). The evaluation of the benefits of drugs may lead to individualized therapy for CKD patients: Cholesterol-lowering treatment for CKD patients with high levels of both LDLc and CRP is suggested.
2021-03-16
2021-03-16
2019
info:eu-repo/semantics/article
Scientific Reports, 2019, vol. 9. 11 p.
2045-2322
http://uvadoc.uva.es/handle/10324/45760
10.1038/s41598-019-45431-5
eng
https://www.nature.com/articles/s41598-019-45431-5
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2019 Springer
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Springer Nature