2026-04-19T05:41:43Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/57972021-06-23T09:47:42Zcom_10324_1132com_10324_931com_10324_894col_10324_1205
All-trans retinol and retinol-binding protein from embryonic cerebrospinal £uid exhibit dynamic behaviour during early central nervous system development
Parada, Carolina
Gato Casado, Ángel Luis
Bueno i Torrens, David
Fluidos orgánicos
Retinol
Embriología humana
Cerebro - Desarrollo
Producción Científica
Embryonic cerebrospinal £uid (E-CSF) is involved in the regulation
of survival, proliferation and neurogenesis of neuroectodermal
progenitor cells, aswell as in the control ofmesencephalic gene expression
in collaboration with the isthmic organizer. Recently, we
showed the presence of retinol-binding protein (RBP) within the
E-CSF proteome.RBP is an all-trans retinol carrier, amolecule that
can be metabolized into retinoic acid, a morphogen involved in
central nervous system (CNS) morphogenesis and patterning.
Here we demonstrate the presence of all-trans retinol within the
E-CSF and analyse the dynamics of RBP and all-trans retinolwithin
this £uid, as well as the expression of retinoic acid-synthesizing
enzymes during early CNS development. Our results suggest
a relationship between the dynamics of these molecules and
the early events of CNS patterning.
2014-09-03
2014-09-03
2008
info:eu-repo/semantics/article
Developmental Neuroscience, June 2008, vol. 19, n. 9. p. 945-950
0378-5866
http://uvadoc.uva.es/handle/10324/5797
945
9
950
Developmental Neuroscience
19
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
Lippincott Williams and Wilkins
Attribution-NonCommercial-NoDerivatives 4.0 International
Lippincott Williams and Wilkins