2024-03-29T08:48:32Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/589722023-03-17T20:02:42Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
Unexpected toxicity of green tea polyphenols in combination with the Sambucus RIL ebulin
Rojo Rodriguez, María de los Ángeles
Garrosa García, Manuel
Jiménez López, María del Pilar
Girbés Juan, Tomás
García Recio, Verónica
Córdoba Diaz, Manuel
Córdoba Diaz, Damián
Polyphenols
Té verde
Lectinas
Producción Científica
The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.
2023-03-17
2023-03-17
2020
info:eu-repo/semantics/article
Toxins, 2020, Vol. 12, Nº. 9, 542
2072-6651
https://uvadoc.uva.es/handle/10324/58972
10.3390/toxins12090542
542
9
Toxins
12
2072-6651
eng
https://www.mdpi.com/2072-6651/12/9/542
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2020 The Authors
Atribución 4.0 Internacional
MDPI