2024-03-29T09:59:40Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/214462021-06-24T07:42:25Zcom_10324_1187com_10324_931com_10324_894com_10324_28542com_10324_952col_10324_1408col_10324_28543
00925njm 22002777a 4500
dc
Guevara Pulido, James Oswaldo
author
Andrés García, José María
author
Pedrosa Sáez, Rafael
author
2014
α,β-Unsaturated aldehydes with aliphatic, electron-poor aromatic, or electron-withdrawing substituents at the β position easily react with different ketones leading to enantioenriched hemiacetals, which were further oxidized to give 4,5,6-trisubstituted-3,4-dihydropyranones in good yields and with excellent enantioselectivities. The behavior of the ketones is dependent on the α substituent of the carbonyl group, and a fine-tuning of the pKa values is necessary to obtain good results.
European Journal of Organic Chemistry, 2014, Volume 2014, Issue 36, p. 8072–8076
1434-193X
http://uvadoc.uva.es/handle/10324/21446
10.1002/ejoc.201402982
8072
36
8076
European Journal of Organic Chemistry
2014
Química orgánica
Organocatalytic Domino Michael-Heterocyclization Reaction of Unsaturated Aldehydes and Cyano Ketones. Synthesis of Enantioenriched 4,5,6-Trisubstituted 3,4-Dihydropyranones