2024-03-29T15:56:59Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/436822021-06-24T07:44:06Zcom_10324_1187com_10324_931com_10324_894com_10324_28542com_10324_952col_10324_1408col_10324_28543
00925njm 22002777a 4500
dc
Martín Maroto, Laura
author
Maestro Fernández, Alicia
author
Andrés García, José María
author
Pedrosa Sáez, Rafael
author
2020
Two novel polymers of intrinsic microporosity decorated with chiral thioureas have been used as recoverable organocatalysts in enantioselective α-amination of 3-aryl-substituted oxindoles, creating a quaternary stereocenter. Both catalysts were able to promote the reaction in excellent yields and good enantioselection. Catalyst II, with a pyridyl nucleus, was used in recycling experiments maintaining the activity without additional reactivation, and in flow processes allowing the synthesis of the amination product in multigram scale.
Organic and Biomolecular Chemistry, 2020, 18, 9275-9283
1477-0520
http://uvadoc.uva.es/handle/10324/43682
10.1039/D0OB01373K
9275
45
9283
Organic & Biomolecular Chemistry
18
1477-0539
Bifunctional thiourea-modified polymers of intrinsic microporosity for enantioselective α-amination of 3-aryl-2-oxindoles in batch and flow conditions