2026-03-13T02:37:06Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/441402021-06-24T07:25:41Zcom_10324_41462com_10324_954com_10324_894col_10324_41463

00925njm 22002777a 4500 dc Soriano, Vicente author Barreiro, Pablo author Ramos, José Manuel author Eiros Bouza, José María author Mendoza, Carmen de author 2020 The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit health-care systems and societies in an unprecedented manner. In 1981, the first cases of AIDS were reported and wide diagnostic testing helped to characterize high-risk groups and the global burden of the epidemic. With Coronavirus Disease (COVID)-19, everything has happened too fast and both cases and fatalities are huge but still uncertain in most places. Diagnostic testing of active and past SARS-CoV-2 infections needs to expand rapidly, ideally using rapid tests. COVID-19 deaths are highly concentrated in the elderly population, with a large proportion of fatalities being "with" rather than "by" SARS-CoV-2 infection. They are often the result of inadequate health care due to overwhelming demands. To date, there is no specific therapy for SARS-CoV-2 infection. Several antivirals are being tested clinically, including remdesivir, at this time the most promising. For others such as lopinavir/ritonavir, neither significant virological nor clinical benefit has been shown. Given the characteristic pulmonary cytokine storm underlying the pathogenic mechanism of severe COVID-19 pneumonia and acute respiratory distress, antiinflammatory agents are being investigated. The benefit of orticosteroids, hydroxychloroquine, etc., is limited. Monoclonal antibodies targeting different pro-inflammatory cytokines, such as tocilizumab, an anti-interleukin 6 agent, are being tried with encouraging results. Ultimately a protective vaccine will be the best response for controlling the COVID-19 pandemic. AIDS Reviews, 2020, vol. 22, n.2, p. 63-77 1139-6121 http://uvadoc.uva.es/handle/10324/44140 10.24875/AIDSRev.M20000030 63 2 77 Aids Reviews 22 1481-4374 COVID-19 comes 40 years after AIDS - any lesson?