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00925njm 22002777a 4500 dc González Martín, Javier author Kraakman, Norbertus Joannes Richardus author Pérez, Cristina author Lebrero Fernández, Raquel author Muñoz Torre, Raúl author 2021 Indoor air pollution has traditionally received less attention than outdoors pollution despite indoors pollutant levels are typically twice higher, and people spend 80–90% of their life in increasing air-tight buildings. More than 5 million people die every year prematurely from illnesses attributable to poor indoor air quality, which also causes multi-millionaire losses due to reduced employee’s productivity, material damages and increased health system expenses. Indoor air pollutants include particulate matter, biological pollutants and over 400 different chemical organic and inorganic compounds, whose concentrations are governed by several outdoor and indoor factors. Prevention of pollutant is not always technically feasible, so the implementation of cost-effective active abatement units is required. Up to date no single physical-chemical technology is capable of coping with all indoor air pollutants in a cost-effective manner. This problem requires the use of sequential technology configurations at the expenses of superior capital and operating costs. In addition, the performance of conventional physical-chemical technologies is still limited by the low concentrations, the diversity and the variability of pollutants in indoor environments. In this context, biotechnologies have emerged as a cost-effective and sustainable platform capable of coping with these limitations based on the biocatalytic action of plants, bacteria, fungi and microalgae. Indeed, biological-based purification systems can improve the energy efficiency of buildings, while providing additional aesthetic and psychological benefits. This review critically assessed the state-of-the-art of the indoor air pollution problem and prevention strategies, along with the recent advances in physical-chemical and biological technologies for indoor pollutants abatement. Chemosphere, 2021, vol. 262, p. 128376 0045-6535 https://uvadoc.uva.es/handle/10324/46747 10.1016/j.chemosphere.2020.128376 128376 Chemosphere 262 A state–of–the-art review on indoor air pollution and strategies for indoor air pollution control