2024-03-29T15:08:26Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/507682023-04-21T08:45:18Zcom_10324_1179com_10324_931com_10324_894col_10324_1306
00925njm 22002777a 4500
dc
Rodrigo Calabia, Emilio
author
Fernandez Fresnedo, Gema
author
Robledo Zulet, Carmen
author
Palomar Fontanet, Rosa
author
Cantarell Aixandri, María del Carmen
author
Mazuecos Blanca, Auxiliadora
author
Osuna Ortega, Antonio
author
Mendiluce Herrero, Alicia
author
Alarcón Zurita, Antonio
author
Arias Rodríguez, Manuel
author
2010
Background. The use of induction drugs has increased markedly over the last 15 years in the USA, but there are few data about their use in other countries. Moreover, there are not enough data about when they are indicated and their long-term effects. The aim of our study was to know the rates of use and the drugs used as induction therapy, in which patients they were prescribed and the long-term graft survival effect in Spain.
Methods. We conducted a retrospective cohort study with adult patients (4861) receiving a kidney allograft in Spain over four different years (1990, 1994, 1998 and 2002) with a functioning graft at the end of the first post-transplant year. Induction therapy was defined as when the patient received polyclonal antibodies, OKT3 monoclonal antibodies or anti-CD25 monoclonal antibodies.
Results. From 1990 to 2002, the use of induction therapy in Spain changed, with a progressive reduction in the use of OKT3 and an increasing use of anti-CD25 antibodies. There were great differences in the rate of induction use from one centre to another, although with a common trend to greater use at each centre. Induction therapy was mainly prescribed in patients with a higher rejection risk (higher panel reactive antibody (PRA) titres and mismatches and re-transplants) and in older and diabetic recipients. Lastly, patients who were treated with induction therapy had significant higher allograft survival than those who did not (P value = 0.035).
Conclusions. The use of induction therapy in Spain has changed, with an increasing use of monoclonal antibodies in recent years. Induction therapy has a protective role in long-term graft survival.
NDT Plus, 2010, vol. 3, supl. 2, p. 9-14
1753-0784
https://uvadoc.uva.es/handle/10324/50768
10.1093/ndtplus/sfq066
10.1016/S0895-7061(99)00261-7
9
suppl 2
14
NDT Plus
3
2048-8513
Riñones - Trasplante
Riñones - Enfermedades - Tratamiento
Heterogeneity of induction therapy in Spain: changing patterns according to year, centre, indications and results