2024-03-29T07:10:51Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/101532021-06-23T09:48:29Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
UVaDOC
author
Kumar, Lalit
author
Pivniouk, Vadim
author
Fuente García, Miguel Ángel de la
author
Laouini, Dhafer
author
Geha, Raif S.
2015-04-08T12:30:39Z
2015-04-08T12:30:39Z
2002
Proceedings of the National Academy of Sciences of the United States of America, 2002, vol. 99, n. 2. p. 884-889
1091-6490
http://uvadoc.uva.es/handle/10324/10153
10.1073 pnas.022619199
884
2
889
PNAS
99
The adapter SLP-76 is essential for thymocyte development. SLP-76−/− mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mice reconstituted with Gads-binding site and SH2 domain deletion mutants had decreased thymic cellularity, impaired transition from double to single positive thymocytes, and decreased numbers of mature T cells in the spleen. Calcium mobilization and extracellular signal-regulated protein kinase activation were decreased in the Gads-binding site mutant but almost normal in the SH2 domain mutant. T cells from both mutants failed to proliferate following T cell antigen receptor ligation. Nevertheless, both mutants mounted partial cutaneous hypersensitivity responses and normal T cell dependent IgG1 antibody responses. These results indicate differential roles for SLP-76 domains in T cell development, proliferation and effector functions.
eng
Attribution-NonCommercial-NoDerivatives 3.0 International
Biología molecular
Differential role of SLP-76 domains in T cell development and function
info:eu-repo/semantics/article
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https://uvadoc.uva.es/bitstream/10324/10153/1/16.M.A.%20de%20la%20Fuente%20PD-229.pdf
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16.M.A. de la Fuente PD-229.pdf