2024-03-29T08:38:41Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/136202021-06-18T10:35:11Zcom_10324_38col_10324_787
UVaDOC
advisor
Rodríguez Cabello, José Carlos
author
Acosta Rodríguez, Sergio
editor
Universidad de Valladolid. Facultad de Ciencias
2015-09-17T19:13:52Z
2017-06-30T23:40:23Z
2015
http://uvadoc.uva.es/handle/10324/13620
Nanotechnology is one of the science fields with a great development in the last
years, with an imperative necessity to produce systems with specific functionalities at
nanometric scale. Nanotechnology has provided sophisticated tools that have
revolutionized many areas of knowledge, such as biomedical science, where enables
improving efficiency and accuracy of current diagnostic techniques, and developing safer
and more effective therapeutics1.
In many cases, these systems are inspired by nature, trying to mimic nanometric
structures formed by proteins and or other macromolecules in the living tissues and cells.
Elastin-Like-Recombinamers (ELRs) are excellent candidates to develop systems that
mimic the extracellular matrix structure due to their smart behavior and their recombinant
nature. And they could be applied for instance, to develop treatments for connective tissue
diseases as arthrosis.
The recombinant nature is one of the most important features of these polymers,
that allows to produce them by recombinant expression in Escherichia coli from predesigned
genes. So we are able to design new materials with enormous potential that
integrate new properties incorporated by genetic engineering for specific applications in
nanomedicine.
The study shown here is focused on the development of new systems intended
for injectable hydrogels in regenerative medicine, and for spherical nanocarriers in drug
delivery. Based on the ability of self-organization into nanostructures demonstrated by
previous amphiphilic tetrablock ELR2, three new copolymers have been developed varying
the individual blocks size, of the original tetrablock ELR. Thus, the aim of this
investigation is to shed light about the influence of the block sizes on the physicochemical
properties and on the structuration of the nanoparticles and of the hydrogels, with the final
goal of setting the basis to perform a rational design from the sequence level.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Nanotecnología - Aplicaciones en Medicina
Synthesis and characterization of amphiphilic elastin-like recombinamers: Development of self-assembling nanoparticles and hydrogels
info:eu-repo/semantics/masterThesis
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