2026-03-08T18:37:42Zhttps://uvadoc.uva.es/oai/request
oai:uvadoc.uva.es:10324/215952021-06-23T09:55:48Zcom_10324_1138com_10324_931com_10324_894col_10324_1226
UVaDOC author Labrador Velandia, Sonia Cecilia author Alonso Alonso, María Luz author Álvarez Sánchez, Sara author González Zamora, Jorge author Pastor Jimeno, José Carlos author Fernández Bueno, Iván author Srivastava, Girish Kumar 2016-12-13T13:04:33Z 2016-12-13T13:04:33Z 2016 World Journal of Stem Cells 2016, 26; 8(11), p. 376-383 1948-0210 http://uvadoc.uva.es/handle/10324/21595 10.4252/wjsc.v8.i11.376 376 383 World Journal of Stem Cells Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases eng Células madre Retina Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials info:eu-repo/semantics/article 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URL https://uvadoc.uva.es/bitstream/10324/21595/1/WJSC-8-376.pdf File MD5 c90eaf083be66975c9712a27fdacae46 743555 application/pdf WJSC-8-376.pdf