2024-03-29T07:14:32Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/461622021-06-24T07:50:21Zcom_10324_40357com_10324_952com_10324_894com_10324_1133com_10324_931col_10324_40358col_10324_1209
UVaDOC
author
Galindo de la Rosa, Sara
author
De La Mata Sampedro, Ana
author
López Paniagua, Marina
author
Herreras Cantalapiedra, José María
author
Pérez Soto, María Inmaculada
author
Calonge, Margarita
author
Nieto Miguel, Teresa
2021-04-13T08:55:01Z
2021-04-13T08:55:01Z
2021
Stem Cell Research & Therapy (2021) 12:60
1757-6512
http://uvadoc.uva.es/handle/10324/46162
https://doi.org/10.1186/s13287-020-02129-0
1
2021 12(60)
12
Stem Cell Research & Therapy
12
Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types, secretion of different trophic factors that promote a regenerative microenvironment, anti-inflammatory actions, selective migration to damaged tissues, and non-immunogenicity. MSCs are effective for the treatment of ocular surface diseases such as dry eye, corneal burns, and limbal stem cell deficiency (LSCD), both in experimental models and in humans. LSCD is a pathological condition in which damage occurs to the limbal epithelial stem cells, or their niche, that are responsible for the continuous regeneration of the corneal epithelium. If LSCD is extensive and/or severe, it usually causes corneal epithelial defects, ulceration, and conjunctival overgrowth of the cornea. These changes can result in neovascularization and corneal opacity, severe inflammation, pain, and visual loss. The effectiveness of MSCs to reduce corneal opacity, neovascularization, and inflammation has been widely studied in different experimental models of LSCD and in some clinical trials; however, the methodological disparity used in the different studies makes it hard to compare outcomes among them. In this regard, the MSC route of administration used to treat LSCD and other ocular surface diseases is an important factor. It should be efficient, minimally invasive, and safe. So far, intravenous and intraperitoneal injections, topical administration, and MSC transplantation using carrier substrata like amniotic membrane (AM), fibrin, or synthetic biopolymers have been the most commonly used administration routes in experimental models. However, systemic administration carries the risk of potential side effects and transplantation requires surgical procedures that could complicate the process. Alternatively, subconjunctival injection is a minimally invasive and straightforward technique frequently used in ophthalmology. It enables performance of local treatments using high cell doses. In this review, we provide an overview of the current status of MSC administration by subconjunctival injection, analyzing the convenience, safety, and efficacy for treatment of corneal failure due to LSCD in different experimental models. We also provide a summary of the clinical trials that have been completed, are in progress, or being planned.
eng
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Subconjunctival injection of mesenchymal stem cells for corneal failure due to limbal stem cell deficiency: state of the art
info:eu-repo/semantics/article
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b3IgaW5jdW1wbGltaWVudG8gZGUgY3VhbHF1aWVyYSBkZSBsYXMgb2JsaWdhY2lvbmVzIGRlcml2YWRhcyBkZWwgQWN1ZXJkbywgcG9yIHZvbHVudGFkIGV4cHJlc2EgZGVsIEF1dG9yCkVuICBwcnVlYmEgZGUgY29uZm9ybWlkYWQsIGxhcyBwYXJ0ZXMgYWNlcHRhbiBlbCBwcmVzZW50ZSBBY3VlcmRvCgoKCgo=
URL
https://uvadoc.uva.es/bitstream/10324/46162/1/2021%20Galindo_et_al-Stem_Cell_Research_%26_Therapy_Subconjunctival%20injection%20of%20MSC%20for%20LSCD.pdf
File
MD5
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application/pdf
2021 Galindo_et_al-Stem_Cell_Research_&_Therapy_Subconjunctival injection of MSC for LSCD.pdf