2024-03-28T11:25:43Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/62882021-06-23T09:48:44Zcom_10324_1133com_10324_931com_10324_894col_10324_1209
UVaDOC
author
Gallego Muñoz, Patricia
author
Martínez García, María del Carmen
author
Pérez Merino, Pablo
author
Ibares Frías, Lucía
author
Mayo Iscar, Agustín
author
Merayo Lloves, Jesús
2014-09-26T16:27:34Z
2015-09-26T23:40:07Z
2012
Ophtalmic and Physiological Optics, 2012, vol. 32, p. 478-484
0275-5408
http://uvadoc.uva.es/handle/10324/6288
10.1111/j.1475-1313.2012.00940.x
478
484
Ophtalmic and Physiological Optics
32
Purpose: To determine the effects of intravitreal atropine on scleral growth in the
form-deprived chick as an experimental model of myopia.
Methods: Five groups of five chicks were studied from day 0–12 post-hatching.
One group remained untreated (C), and four were form-deprived by monocular
light diffusers to induce myopia. Two groups (RL and A) wore diffusers for
9 days, and the other two groups (D and D + A) wore diffusers throughout the
study. Group D received no further treatment (myopia positive control). Groups
A and D + A received intravitreal injections of atropine for days 9–12. Measurements
of refractive error and axial length were performed on days 0, 9, and 12.
Sclera changes were assessed in cartilaginous and fibrous layers by histological
analysis.
Results: All form-deprived eyes had a myopic refractive error on day 9. All atropine-
treated groups were hyperopic on day 12. The effect of atropine was most
evident in Group D + A in which diffusers were maintained throughout treatment
and changes in refractive error were statistically significant. The observed
changes in axial length were in line with the changes in refractive error. The scleral
fibrous layer thickness increased, and the sceral cartilaginous layer underwent a
slight thinning compared to Group D, the myopia positive control.
Conclusions: If the signals that induce growth remain during atropine treatment,
morphological changes in sclera are produced: the scleral fibrous layer thickened,
and the sceral cartilaginous layer thinned. These changes resulted in refractive
error recovery, and the ocular growth was stopped. The data suggested the atropine
was acting throughout the scleral fibrous layer.
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
Miopia - Tratamiento
Scleral changes induced by atropine in chicks as an experimental model of myopia
info:eu-repo/semantics/article
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