2024-03-28T10:04:56Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/469662021-06-23T09:53:22Zcom_10324_1134com_10324_931com_10324_894col_10324_1213
Prieto Lloret, Jesús
Ramírez Arroyo, María
Olea Fraile, Elena
Moral Sanz, Javier
Cogolludo Torralba, Ángel
Castañeda, Javier
Yubero Benito, Sara
Agapito Serrano, María Teresa
Gómez Niño, María Ángeles
Rocher Martín, María Asunción
Rigual Bonastre, Ricardo Jaime
Obeso Cáceres, Ana María de la Luz
Pérez Vizcaíno, Francisco
González, Constancio
2021-06-21T11:25:11Z
2021-06-21T11:25:11Z
2015
The Journal of Physiology, 2015, vol. 593, n. 11. p. 2459-2477
1469-7793
https://uvadoc.uva.es/handle/10324/46966
10.1113/JP270274
Adult mammalians possess three cell systems that are activated by acute bodily hypoxia: pulmonary artery smooth muscle cells (PASMC), carotid body chemoreceptor cells (CBCC) and erythropoietin (EPO)-producing cells. In rats, chronic perinatal hyperoxia causes permanent carotid body (CB) atrophy and functional alterations of surviving CBCC. There are no studies on PASMC or EPO-producing cells. Our aim is to define possible long-lasting functional changes in PASMC or EPO-producing cells (measured as EPO plasma levels) and, further, to analyse CBCC functional alterations. We used 3- to 4-month-old rats born and reared in a normal atmosphere or exposed to perinatal hyperoxia (55–60% O2 for the last 5–6 days of pregnancy and 4 weeks after birth). Perinatal hyperoxia causes an almost complete loss of hypoxic pulmonary vasoconstriction (HPV), which was correlated with lung oxidative status in early postnatal life and prevented by antioxidant supplementation in the diet. O2-sensitivity of K+ currents in the PASMC of hyperoxic animals is normal, indicating that their inhibition is not sufficient to trigger HPV. Perinatal hyperoxia also abrogated responses elicited by hypoxia on catecholamine and cAMP metabolism in the CB. An increase in EPO plasma levels elicited by hypoxia was identical in hyperoxic and control animals, implying a normal functioning of EPO-producing cells. The loss of HPV observed in adult rats and caused by perinatal hyperoxia, comparable to oxygen therapy in premature infants, might represent a previously unrecognized complication of such a medical intervention capable of aggravating medical conditions such as regional pneumonias, atelectases or general anaesthesia in adult life.
eng
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2015 The Journal of Physiology
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Hypoxic pulmonary vasoconstriction, carotid body function and erythropoietin production in adult rats perinatally exposed to hyperoxia
info:eu-repo/semantics/article