2026-04-15T19:21:24Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/57972021-06-23T09:47:42Zcom_10324_1132com_10324_931com_10324_894col_10324_1205

All-trans retinol and retinol-binding protein from embryonic cerebrospinal £uid exhibit dynamic behaviour during early central nervous system development Parada, Carolina Gato Casado, Ángel Luis Bueno i Torrens, David Fluidos orgánicos Retinol Embriología humana Cerebro - Desarrollo Producción Científica Embryonic cerebrospinal £uid (E-CSF) is involved in the regulation of survival, proliferation and neurogenesis of neuroectodermal progenitor cells, aswell as in the control ofmesencephalic gene expression in collaboration with the isthmic organizer. Recently, we showed the presence of retinol-binding protein (RBP) within the E-CSF proteome.RBP is an all-trans retinol carrier, amolecule that can be metabolized into retinoic acid, a morphogen involved in central nervous system (CNS) morphogenesis and patterning. Here we demonstrate the presence of all-trans retinol within the E-CSF and analyse the dynamics of RBP and all-trans retinolwithin this £uid, as well as the expression of retinoic acid-synthesizing enzymes during early CNS development. Our results suggest a relationship between the dynamics of these molecules and the early events of CNS patterning. 2014-09-03T08:46:02Z 2014-09-03T08:46:02Z 2008 info:eu-repo/semantics/article Developmental Neuroscience, June 2008, vol. 19, n. 9. p. 945-950 0378-5866 http://uvadoc.uva.es/handle/10324/5797 945 9 950 Developmental Neuroscience 19 eng Attribution-NonCommercial-NoDerivatives 4.0 International info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Lippincott Williams and Wilkins application/pdf Lippincott Williams and Wilkins