2026-03-16T17:47:16Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/833152026-03-03T20:01:15Zcom_10324_1181com_10324_931com_10324_894col_10324_1387

Resting-state gamma activity as a discriminative marker for cognitive subtypes in psychosis Osorio Iriarte, María Emma Díez Revuelta, Álvaro Fernández Linsenbarth, Ines Arjona Valladares, Antonio Beño Ruiz De La Sierra, Rosa María Roig Herrero, Alejandro Martínez Sánchez, José María Sobrino Conde, Luis Molina Rodríguez, Vicente Electroencephalography Resting-state EEG Gamma band Schizophrenia Biomarker 3211 Psiquiatría Producción Científica Background and hypothesis: Schizophrenia and other psychotic disorders exhibit significant clinical and cognitive heterogeneity, challenging diagnosis and treatment. Given indications of widespread cortical hyperactivity and dysregulation of neural oscillations in schizophrenia, investigating resting-state activity is highly relevant. This study examined resting-state EEG alterations across previously defined cognitive subtypes within the psychosis spectrum. Study design: We analyzed resting-state EEG data from 141 psychosis patients (64 chronic schizophrenia, 40 first- episode schizophrenia, 37 bipolar disorder) and 80 healthy controls. Patients were a priori classified into two distinct cognitive subgroups: Cluster 1 (severe impairment, n = 47) and Cluster 2 (moderate impairment, n = 94). Study results: Both patient clusters exhibited increased spectral power across most frequency bands compared to healthy controls. Notably, the more severely impaired Cluster 1 showed significantly higher power in the gamma-1 band (30–45 Hz) compared to Cluster 2. Furthermore, in Cluster 1, a significant positive correlation was found between resting-state gamma-1 power and positive symptom scores. Conclusions: These results support our hypothesis of distinctive basal hyperactivation linked to the cognitive profile, suggesting that altered intrinsic brain activity, particularly gamma-1 hyperactivation, may underlie cognitive heterogeneity in psychosis. This also suggests that gamma-1 band hyperactivation at rest serves as a distinct neurophysiological marker differentiating both subgroups. Our findings highlight the importance of subdivision approaches to identify more homogeneous patient subgroups and emphasize the potential of resting- state gamma activity as a precise biomarker for specific symptom dimensions and personalized treatment strategies. Instituto de Salud Carlos III (ID PI22/00465) Junta de Castilla y León - Gerencia Regional de Salud de Castilla y León (GRS-2487/A/22 y GRS-2685/A1/2023) Fundación La Marató (ID 571/C/2022) Junta de Castilla y León (Consejería de Educación) y el Fondo Social Europeo (ID VA-229-23 a la EOI) Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación (PRE2022–104038) 2026-03-03T12:22:19Z 2026-03-03T12:22:19Z 2026 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://doi.org/10.1016/j.pnpbp.2026.111646 Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2026, vol. 145, p. 111646 0278-5846 https://uvadoc.uva.es/handle/10324/83315 111646 Progress in Neuro-Psychopharmacology and Biological Psychiatry 145 eng https://www.sciencedirect.com/science/article/pii/S0278584626000424 Atribución 4.0 Internacional info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ © 2026 The Author(s) application/pdf Elsevier