2024-03-28T22:38:07Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/83652021-06-23T09:46:44Zcom_10324_1131com_10324_931com_10324_894col_10324_1201
Local sclerotherapy with Polydocanol (Aethoxysklerol®) for the treatment of Epistaxis in Rendu-Osler-Weber or Hereditary Hemorrhagic Telangiectasia (HHT): 15 years of experience*
Morais Pérez, Darío
Millás, Teresa
Zarrabeitia Puente, Roberto
Botella, Luisa M.
Almaraz Gómez, Ana
Cardiovascular, Aparato - Enfermedades
Producción Científica
Hereditary Haemorrhagic Telangiectasia or Rendu-Osler-Weber syndrome is a rare autosomal dominant vascular disease characterized by mucocutaneous and gastrointestinal telangiectases and localized arteriovenous malformations in lung, brain and liver. Epistaxis, due to rupture of telangiectases of the nasal mucosa, is the most frequent clinical manifestation, leading in many cases to severe impairment of the quality of life in the patients. Though several treatments have been used to reduce epistaxis, none have been completely effective, with the exception of polydocanol (Aethoxysklerol®) in submucosal or subpericondrial injections, which was first presented in 2000 with very good results. After fifteen years using polydocanol in submucosal injections on 45 patients and with nearly 300 injections, we have observed that in 95% of all cases, their nose bleeds improved with respect to frequency and quantity without any important side effects. There was just one case of septal perforation, another with increased septal perforation, and one patient who suffered from dizziness and blurred vision for a few minutes. In this paper the results obtained using this technique over a fifteen-year period will be presented and evaluated.
2015-02-16T11:43:38Z
2015-02-16T11:43:38Z
2012
info:eu-repo/semantics/article
https://doi.org/10.4193/Rhino11.142
Rhinology. 2012 Mar;50(1):80-86
0300-0729
http://uvadoc.uva.es/handle/10324/8365
80
1
86
Rhinology
50
eng
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
application/pdf
Rhrinology Secretary