2024-03-28T14:50:42Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/353292021-06-24T07:27:36Zcom_10324_22821com_10324_954com_10324_894col_10324_22822
A novel information criterion to elucidate a drug delivery mechanism from poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced with hydroxyapatite composite
García Couce, Jomarien
Campos, Yaima
Torres, Susana
Peón, Eduardo
Fuentes, Gastón
Almirall, Amisel
Delgado, José Ángel
Rodríguez Cabello, José Carlos
Cruz Ricondo, Luis J.
Hydrophilic composites of poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced with
hydroxyapatite were synthesized, characterized and evaluated as drug delivery systems. The results show a strong dependence of the polymer composition, the degree of crosslinking and the homogeneity of the particles dispersion (filler or the mixed drug) in the characteristics that were analyzed. The mechanical properties were better while the swelling and the diffusion coefficient were worse than hydrogels with cefazolin of similar compositions. Additionally, a new information criterion
was used to elucidate the best fit. The drug diffusion into the medium was anomalous with a tendency towards Case II transport, indicating that under certain conditions zero-order diffusion could be achieved. This fact suggests that these materials could be used in the manufacture of medical devices for the controlled delivery of drugs and active or biological principles, significantly improving therapeutic procedures today.
2018
info:eu-repo/semantics/article
Polymer, 2018, vol. 158. p. 279-288
0032-3861
http://uvadoc.uva.es/handle/10324/35329
https://doi.org/10.1016/j.polymer.2018.10.068
eng
https://www.sciencedirect.com/science/article/pii/S0032386118309959
info:eu-repo/semantics/openAccess
© 2019 Elsevier
Elsevier