2024-03-29T06:25:30Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/446062021-06-24T07:36:42Zcom_10324_1134com_10324_931com_10324_894com_10324_32522com_10324_952com_10324_43677com_10324_954col_10324_1213col_10324_32523col_10324_43678
Are Kv channels the essence of O2 sensing?
Pérez García, María Teresa
López López, José Ramón
This report represents a relevant contribution to the study of oxygen sensing for two main reasons. First, it shows an approach adequate for identification of a putative O2-sensitive K+ channel, by moving from the modulation by hypoxia of a recombinant channel back to its physiological context, the role of this channel in the response to low Po2 of the native cells. Second, it demonstrates that hypoxic inhibition of the recombinant Kv3.1 channels is retained in excised membrane patches, pointing to a membrane-delimited mechanism as the origin of hypoxic responses. The importance of this latter finding deserves additional comment.
2020-12-28T12:48:36Z
2020-12-28T12:48:36Z
2020-12-28T12:48:36Z
2000
info:eu-repo/semantics/article
Circulation Research, 2000, vol. 86, n. 5. p. 490-491
1524-4571
http://uvadoc.uva.es/handle/10324/44606
10.1161/01.RES.86.5.490
eng
https://www.ahajournals.org/doi/10.1161/01.RES.86.5.490
info:eu-repo/semantics/openAccess
© 2000 American Heart Association
American Heart Association