2024-03-29T06:55:38Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/575032022-11-28T20:00:40Zcom_10324_1132com_10324_931com_10324_894col_10324_1205
Retinoic acid, under cerebrospinal fluid control, induces neurogenesis during early brain development
Alonso Revuelta, María Isabel
Carnicero Gila, Estela María
Carretero, Raquel
Mano Bonín, Anibal de la
Moro Balbás, José Antonio
Lamus Molina, José Francisco
Martín, Cristina
Gato Casado, Ángel Luis
One of the more intriguing subjects in neuroscience is how a precursor or stem
cell is induced to differentiate into a neuron. Neurogenesis begins early in brain development
and suddenly becomes a very intense process, which is related with the influence of
Retinoic Acid. Here, using a biological test (F9-1.8 cells) in chick embryos, we show that
―in vivo‖ embryonic cerebrospinal fluid regulates mesencephalic-rombencephalic Isthmic
Retinoic Acid synthesis and this effect has a direct influence on mesencephalic neuroepithelial
precursors, inducing a significant increase in neurogenesis. This effect is mediated by the
Retinol Binding Protein present in the embryonic cerebrospinal fluid. The knowledge of
embryonic neurogenetic stimulus could be useful in the control of adult brain neurogenesis.
2022-11-28T13:11:37Z
2022-11-28T13:11:37Z
2022-11-28T13:11:37Z
2014
info:eu-repo/semantics/article
Journal of Developmental Biology, 2014, vol. 2, n. 2, p. 72-83
2221-3759
https://uvadoc.uva.es/handle/10324/57503
10.3390/jdb2020072
72
2
83
Journal of Developmental Biology
2
2221-3759
eng
https://www.mdpi.com/2221-3759/2/2/72
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
© 2014 The Author(s)
http://creativecommons.org/licenses/by/3.0/
MDPI