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oai:uvadoc.uva.es:10324/214522021-06-24T07:42:20Zcom_10324_1187com_10324_931com_10324_894com_10324_28542com_10324_952col_10324_1408col_10324_28543

Enantioselective Synthesis of Seven-Membered Carbo- and Heterocyles by Organocatalyzed Intramolecular Michael Addition Guevara Pulido, James Oswaldo Andrés García, José María Ávila, Deisy P. Pedrosa Sáez, Rafael Química orgánica Producción Científica Unprecedented diastereo- and enantioselective synthesis of seven-membered rings has been achieved by organocatalyzed intramolecular Michael addition of enals bearing β-diketone functionality. The cyclization leads to 2,3-disubstituted cycloheptanone derivatives in high yield and excellent stereoselectivity. The same organocatalyzed cyclization process has been used to prepare six-membered homologs, but with lower stereoselectivity. 2016-12-05T13:48:27Z 2016-12-05T13:48:27Z 2016 info:eu-repo/semantics/article RSC Advances, 2016, 6, p. 30166-30169 http://uvadoc.uva.es/handle/10324/21452 10.1039/C6RA04198A 30166 6 30169 RSC Advances eng http://pubs.rsc.org/ info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Royal Society of Chemistry SI